Question
5. In the synthesis of aspirin, what is the purpose of ;a) The sulfuric acid?b) The hot water bath?c) The ice bath?d) Adding distilled water in the reaction flask, before puttingthe flask in an ice bath?Q2 ). After the aspirin has been filtered;a) Why is it washed with distilled water?b) Why is ice cold distilled water used, instead of roomtemperature water, to wash the aspirin?c) Why is the vacuum hose disconnected when washing the aspirinwith distilled water?
5. In the synthesis of aspirin, what is the purpose of ; a) The sulfuric acid? b) The hot water bath? c) The ice bath? d) Adding distilled water in the reaction flask, before putting the flask in an ice bath? Q2 ). After the aspirin has been filtered; a) Why is it washed with distilled water? b) Why is ice cold distilled water used, instead of room temperature water, to wash the aspirin? c) Why is the vacuum hose disconnected when washing the aspirin with distilled water?
Chemistry 101
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With reference to the structures of acetylsalicylic acid (aspirin, Chapter 2 opening molecule) and
acetaminophen (the active ingredient in Tylenol), explain each statement: (a) Acetaminophen
tablets can be stored in the medicine cabinet for years, but aspirin slowly decomposes over time;
(b) Children's Tylenol can be sold as a liquid (acetaminophen dissolved in water), but aspirin cannot.
This problem is what we call a back titrate Asian problem, where we add excess amount of sodium hydroxide and then determine the amount of excess. And the difference will then be the sodium hydroxide that reacted with our compound were interested in the aspirin. So to answer this question, the first thing we need to do is figure out the total moles of sodium hydroxide that we added, which will be the volume of sodium hydroxide, 50 mL or point of five leaders multiplied by its mill arat E. Then we need to subtract off the moles that didn't react with aspirin. Those air the moles of sodium hydroxide in excess that we determined with the addition of 31.96 mL, or 0.3196 liters off hydrochloric acid at a concentration of 0.29 So this is the moles of H. C. L. That was required to neutralize the excess sodium hydroxide. And because the reaction is one toe one, this is also the excess moles of sodium hydroxide. So this difference then tells us the moles of sodium hydroxide that reacted with the aspirin. So the percent aspirin is going to be the moles of aspirin, which, if we look at the stoy geometry of the reaction given for every mole of sodium hydroxide. We need two moles of sorry for every mole of aspirin. We need two moles of sodium hydroxide so we can take the moles of sodium hydroxide. We calculated and converted two moles of aspirin with the 2 to 1 relationship and then convert the moles of aspirin into grams of aspirin using the molar mass of aspirin. Divide that by the mass of the sample and multiplied by 100 to get our percent, that is aspirin. If we look at the balanced chemical reaction, we see two products. We see the fallacy laid eye on, and we see the acetate eye on those air. Both conjugate acid. Both those were both conjugate. Base is too weak acids, so they themselves are weak bases because they are basic, then the indicator that we choose needs to have a basic transition range, probably something around a transition range of eight or so. In order to determine the end point of this tie, Trish in
For the given caution. We have the balance chemical equation for the reaction off aspirin with any which represented over here. Firstly, we need to calculate the moles off aspirin on moored off anyway. It's on the morning off at Seal, which is used to react the excess off hydroxide remaining in the solution. Morning off aspirin molds off any witch and moons off, etc. L. Orla, calculated by the same base since the ex SEAL, react with the excess off hydroxide, the amount off any which was consumed. So the aspirin is follow over here from balancing the equation. We know that for every two moles off base, which negative only one mole off aspirin is consumed, we let the calculate the mold off aspirin needed two moles off which over here we have the calculation representation. We need to calculate the purity off aspirin using the formula, which is represented. The purity calculated is 99.7%. Finally, for this iteration, as indicators should be used, that changes color in the range off Piquet off aspirin is three point fight, So the broom off in all blue is the indicator which we can use
Yeah, The explanation of the solution is that for the part A the hybridization off C in C S three is SP three as c forms for Sigma born. All other si atoms are SP two hybridized as C 43 Sigma Bonds now or Adam in the two CEO group. It's SP three hybridized as all forms to Sigma Bond and has two lone pair off electrons si atom in C double bond Oh group is aspecto hybridize as it form three sigma bonds for the part B bones outside the ring are localized bones hence to bones are localized for the part C carbon atom which is SP toe hybridized has diagonal planet shape around itself the Tetra Hadel planner ship and one C atom which has the Tetra Hurdle say so. This is the explanation off the solution. Please go through this. Thank you
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FAQs
What is the purpose of synthesis of aspirin? ›
In 1897, Felix Hoffmann discovered that there was indeed a way to make this drug less irritating to the throat and stomach: by reacting Salicylic acid with Acetic Anhydride, it would be possible to acetylate the Salicylic acid to remove one of these proton-donating groups and thus make it less irritating to the body.
What is the purpose of salicylic acid in the synthesis of aspirin? ›To prepare aspirin, salicylic acid is reacted with an excess of acetic anhydride. A small amount of a strong acid is used as a catalyst which speeds up the reaction.
What is the main reaction in the synthesis of aspirin? ›The synthesis of aspirin is known in organic chemistry as an esterification reaction. This is a substitution reaction in which an alcohol (the –OH group in salicylic acid) reacts with acetic anhydride to form an ester, aspirin.
What is the purpose of sulfuric acid in the synthesis of aspirin? ›Making aspirin
In this case just a few drops of sulphuric acid added to the mixture means that there are some free positive hydrogen ions in the solution which can bind to the ethanoic anhydride. This makes it more active and speeds up the reaction.
Any remaining contaminants are removed by recrystallization in a solvent in which aspirin is sparingly soluble. Aspirin separates then as crystals leaving impurities behind in solution. This process should give a relatively clean product, whose purity can be determined by melting point analysis.